Metformin for diabetes prevention: update of the evidence base
نویسندگان
چکیده
We have conducted a narrative review based on structured search strategy, focusing the effects of metformin progression non-diabetic hyperglycemia to clinical type 2 diabetes mellitus. The principal trials that demonstrated significantly lower incidence in at-risk populations randomized (mostly with impaired glucose tolerance [IGT]) were published mainly from 1999 2012. Metformin reduced 3-year risk by ?31% phase Diabetes Prevention Program (DPP), vs. ?58% for intensive lifestyle intervention (ILI). was most effective younger, heavier subjects. Diminishing but still significant reductions subjects originally these groups present trial’s epidemiological follow-up, DPP Outcomes Study (DPPOS) at 10 years (?18 and ?34%, respectively), 15 ?27%), 22 ?25%). Long-term weight loss also seen both groups, better maintenance under metformin. Subgroup analyses DPP/DPPOS shed important light actions metformin, including greater effect women prior gestational diabetes, reduction coronary artery calcium men might suggest cardioprotective effect. Improvements long-term outcomes people (“prediabetes”) yet be demonstrated, cardiovascular microvascular benefits those DPPOS who did not develop diabetes. Multiple health economic either or ILI is cost-effective community setting. prevention feasible supported influential guidelines selected Future research will demonstrate whether improve outcomes.
منابع مشابه
Metformin for prevention of type 2 diabetes.
OBJECTIVE To evaluate evidence from the medical literature that metformin is effective in preventing type 2 diabetes. DATA SOURCES Primary literature was accessed via a MEDLINE search (1966-December 2003) using the terms metformin, type 2 diabetes, and prevention. DATA SYNTHESIS Two studies evaluated metformin's potential to prevent type 2 diabetes, finding that metformin maintained or redu...
متن کاملstudy of cohesive devices in the textbook of english for the students of apsychology by rastegarpour
this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
the use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach
abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...
15 صفحه اولEffects of withdrawal from metformin on the development of diabetes in the diabetes prevention program.
OBJECTIVE In the Diabetes Prevention Program (DPP), metformin significantly reduced the risk of diabetes in individuals with impaired glucose tolerance. Diabetes status was assessed by oral glucose tolerance tests (OGTTs) performed while participants were still taking metformin or placebo. To determine whether the observed benefit was a transient pharmacological effect or more sustained, we per...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Medical Research and Opinion
سال: 2021
ISSN: ['0300-7995', '1473-4877']
DOI: https://doi.org/10.1080/03007995.2021.1955667